SLC7A11, a cystine transporter, has been identified as a potential therapeutic target in PDAC … Mucinous cystadenoma is a benign cystic tumor lined by a mucinous epithelium. Complete surgical removal of the tumor remains the only chance for cure, however 80-90% of patients have disease that is surgically incurable at the time of clinical presentation (15). PDAC is an aggressive and difficult malignancy to treat. Immune evasion is a major obstacle for cancer treatment. Here, we evaluate the impact of high-iron diets or depletion of Gpx4, an antioxidant enzyme reported as an important ferroptosis suppressor, in the pancreas of mice with cerulean- or L-arginine-induced pancreatitis, and in an oncogenic Kras murine model of spontaneous pancreatic ductal adenocarcinoma (PDAC). Cancer-Associated Fibroblasts (CAF) are major contributors to pancreatic ductal adenocarcinoma (PDAC) progression through pro-tumor signaling and the generation of fibrosis that creates a physical barrier to drugs. Common mechanisms of evasion include impaired antigen presentation caused by mutations or loss of heterozygosity of the major histocompatibility complex class I (MHC-I), which has been implicated in resistance to immune checkpoint blockade (ICB) therapy 1-3.However, in pancreatic ductal adenocarcinoma (PDAC), which … Adenocarcinoma of the pancreas: Adenocarcinoma of the pancreas can present as chronic epigastric pain, also known as pain directly below your ribcage in the upper abdomen. It is a type of cystic adenoma (cystadenoma).. Mucinous cystadenomata may arise in a number of locations; however, mucinous cystadenoma at different locations are not generally considered to be related to one another. CAF inhibition is thus an ideal component of any therapeutic approach for PDAC. Pancreatic ductal adenocarcinoma (PDAC) is the most common malignancy of the pancreas. Other symptoms may include nausea, vomiting, jaundice, unexplained weight loss, anorexia, abnormal weakness, oily stool, swelling of the liver and spleen, and blood clots.
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