Maria Guido MD, in Practical Hepatic Pathology, 2011. 4 ... • Chronic hepatitis • Granulomatous hepatitis • Steatosis / steatohepatitis Most patients with SLE do not have significant liver pathology but chronic hepatitis, cirrhosis and hepatic granulomas have been reported. Surgical Pathology report of liver biopsies for regularly encountered medical liver diseases. Keywords: Hepatitis C, Liver pathology, Biopsy, Grading, Staging, Neoplasia Core tip: The manuscript is a comprehensive review of liver pathology of hepatitis C infection. CHRONIC HEPATITIS The work of the two decades preceding the Knodell HAI provided the foundation for our current understanding of the histopathology of chronic hepatitis. This review is limited to grading and staging of CH, such as viral and autoimmune hepatitis, and does not include discussion of steatohepatitis. Early descriptions and classifications focused on differentiating acute and chronic hepatitis and on lesions that predicted disease progression. Batts KP and Ludwig J. Need for Grading and Staging. 2017 May;30(5):773. Am J Surg Pathol 1995;19(12):1409-1417. It outlines the goals and basic elements of grading and staging, a historical perspective, and the common currently used systems. Chronic Hepatitis Grading and Staging (Batts and Ludwig, 1995) Grading of Chronic Viral Hepatitis Activity and Fibrosis (Scheuer, 1991) Knodell Score (Histology Activity Index- HAI Score) (Knodell et al., 1981) Autoimmune Hepatitis ... • Chronic hepatitis grading and staging bx minimum criteria – ≥ 20-25 mm long – ≥ 11 complete portal tracts . Chronic hepatitis an update on terminology and reporting. 283,284 Abnormal liver function tests may be present without serious lesions. predominant pathology if more than one cause of liver injury is present. 1 , 2 , 3 CAS Article PubMed Central Google Scholar AUTOIMMUNE HEPATITIS Balitzer D, Shafizadeh N, Peters MG, Ferrell LD, Alshak N, Kakar S. Autoimmune hepatitis: review of histologic features included in the simplified criteria proposed by the international autoimmune hepatitis group and proposal for new histologic criteria. Czaja AJ, Ludwig J, Baggenstoss AH, Wolf A (1981) Corticosteroid-treated chronic active hepatitis in remission: uncertain prognosis of chronic persistent hepatitis. Please mail comments, corrections or … Modern Pathology. N Engl J Med 304(1):5–9 PubMed CrossRef Google Scholar Long term effects of phlebotomy on biochemical and histological parameters of chronic hepatitis C. Am J Gastroenterol 2002;97:133–137. Although the putative fate of any chronic hepatitis, regardless of etiology, is progression to cirrhosis, the rate of progression and its inevitability varies widely among individuals, depending presumably on characteristics of the disease process as well as those of the host.
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